To be clear, because some people mis-undesrtood my problem. I need to have portable version of Miranda to publish it for several users manually and also as RemoteApp. When it's normal instalaton, it just doesn't work because of permissions. Adding new permissions to folder for portable version shouldn't be a reason becasue, obviously it should work out-of-the-box everywhere for all users, especially it's main folder , not some specific folder with specific permissions.
Wishmaster, like i said, it's portable version so, how it would want to create profile in Appdata if this version supposed to be portable? This doesn't make sense.
White-Tiger, please read whole topic before you post, because all your suggestions or possibilites i wrote posts ago, aren't solutions for using Miranda in future - but i'll reapet that, it shouldn't be like that i every time need to change permissions if there are portable software that works fine with this folder permisions. Also, if you would read my VI, you would see it's WS 2012E so, it's obviously not a upgraded OS (one option would be WHS2011 but that didn't happen).