Strange but since my post there was no hang. The only thing changed - updated my antivirus software. So still waiting for chance to get additional data if it happens.
About profile size - it was used to be about 300 MB but i deleted some parts of history. How to get such large profile? Just subscribe to some bots
In my case this is required for my work.
'Portable' here means packed as part of PortableApps suite. However on major changes on my PC inspecting in profile setting required - sometimes some paths are saved as is (without variables).
Also i can say that those hangs seemed to happen on receiving new message. Especially often on startup when there is a lot of them.