Sitting with 8 GB och ram, and I just tested to send a 2.5 GB file and the ammount of RAM used did not change significantly, neither for miranda or as a whole. So I don't think that is the issue. Miranda kept below.
Process Hacker did not show any kind of increase or decrease of RAM during initiating of transfer nor when it was accepted and had run for a moment.
So, am I the only one who can't send files larger than 4 GB, or a number of files with a combined size larger than 4 GB? It's strange that when attempting to send numerous files such a thing should matter as it should only care about the next file in order to send.